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Procalcitonin (PCT)

A marker of systemic bacterial infection and sepsis. Helps distinguish bacterial from viral inflammation.

Other names: Procalcitonin, PCT Section: Blood chemistry
In shortProcalcitonin is nearly absent from blood in health but rises with bacterial infection in proportion to severity. Viral infections usually leave it low. The test is used mainly in hospitals to diagnose sepsis and to guide antibiotic decisions.

Reference ranges

GroupReference range
Outside bacterial infection — typical range (international reference, not a national standard)low level; exact cutoffs depend on the assay
MedlinePlus describes the test qualitatively: results are read against the assay's thresholds together with the clinical picture. No single standard range applies. Reference ranges vary between laboratories and assays — use the range printed on your own lab report.

Check your value

Enter your result — we will show how it compares with a typical range. Match the units of the selected row.

Approximate comparison with a typical range, not a diagnosis. Reference intervals vary by laboratory and method — check your report; result interpretation is done by a doctor.

What this marker is

PCT is the precursor of the hormone calcitonin. In bacterial infection many tissues release it, and the level tracks the severity of the systemic response; it falls quickly with effective treatment.

Clinicians use PCT to support decisions about starting and stopping antibiotics — for example in pneumonia — always together with the clinical picture.

When it is high

SepsisA marked elevation signals systemic bacterial infection — an emergency.
Bacterial infectionsPneumonia, pyelonephritis, and meningitis raise the level; the trend reflects treatment effect.
Major trauma and burnsMassive tissue damage can elevate PCT without infection.

When it is low

Viral infection or localized processA low level makes systemic bacterial infection unlikely.

What can skew the result

These factors can shift the value without any disease — worth considering before a retest:

Major trauma and burnsRecent extensive surgeryKidney function

How to prepare

No special preparation; the test is performed for clinical indications, usually in hospital.

When a retest makes sense

In hospital — by clinical need, often daily or every other day to follow the trend.

Who usually reviews this result

A result outside the reference range is usually reviewed by: your GP or primary care doctor; an infectious disease specialist or intensivist in hospital. Bring your lab report and any previous results to the appointment.

Names used on lab reports

Your report may use any of these names:
ProcalcitoninPCT

Units and conversion

Measured in: ng/mL

ng/mL = µg/L
1 ng/mL = 1 µg/L — the number stays the same. Results are rounded to 2 decimal places.

Several markers on your report?

See how MedProtect explains results in the app: the whole report, a check of the recognized values, and a clear breakdown.

Frequently asked questions

How does PCT differ from CRP?
PCT is more specific for bacterial infection and falls faster with recovery; CRP rises with any inflammation.
Is it ordered for a common cold?
No — mild viral illness does not need it; the test addresses suspected severe bacterial infection.
Can PCT be high without infection?
Yes — with major trauma, burns, extensive surgery, and some tumors (medullary thyroid cancer).

Sources

  1. Procalcitonin test: MedlinePlus Medical Test — MedlinePlus. Accessed: August 31, 2026.

See also