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Apolipoprotein A-I (ApoA1)
The main protein of HDL particles. Higher levels are associated with lower cardiovascular risk.
Other names: Apolipoprotein A-I, ApoA1Section: Blood chemistry
Updated: August 31, 2026·MedProtect editorial team Reference information — not a diagnosis or a prescription
In shortApoA1 is the structural protein of HDL — the particles that carry cholesterol back to the liver. A typical range is about 100–150 mg/dL (1.0–1.5 g/L). Unlike most lipid markers, a low ApoA1 is the unfavorable finding; it is evaluated together with ApoB.
Reference ranges
Group
Reference range
Adults — typical range (international reference, not a national standard)
about 100–150 mg/dL (1.0–1.5 g/L)
Typical range from Cleveland Clinic patient information (international reference, not a national standard). The report's own interval applies. Reference ranges vary between laboratories and assays — use the range printed on your own lab report.
Check your value
Enter your result — we will show how it compares with a typical range. Match the units of the selected row.
Approximate comparison with a typical range, not a diagnosis. Reference intervals vary by laboratory and method — check your report; result interpretation is done by a doctor.
What this marker is
ApoA1 activates the enzymes of reverse cholesterol transport, moving cholesterol from tissues to the liver for disposal. The more ApoA1, the more efficient this protective pathway.
The ApoB/ApoA1 ratio — the balance of atherogenic to protective particles — is among the most informative lipid-derived risk markers.
When it is high
Favorable findingA moderately high ApoA1 is protective; it is seen in physically active people.
When it is low
Cardiovascular riskLow ApoA1 is associated with increased atherosclerotic risk.
Inherited deficienciesRare genetic defects of ApoA1 synthesis (such as Tangier disease) give very low values.
Smoking and diabetesLifestyle and metabolic disorders lower the level.
What can skew the result
These factors can shift the value without any disease — worth considering before a retest:
Physical activitySmokingEstrogen therapyDiabetes
How to prepare
Fasting 8–12 hours; usually part of an extended lipid panel with ApoB.
When a retest makes sense
An abnormal result is rechecked with the lipid panel and ApoB after 2–3 months.
Who usually reviews this result
A result outside the reference range is usually reviewed by: your GP or primary care doctor; a cardiologist for risk assessment. Bring your lab report and any previous results to the appointment.
Names used on lab reports
Your report may use any of these names: ApoA1ApoA-IApolipoprotein A-I
Units and conversion
Measured in: mg/dL
mg/dL=g/L
g/L = mg/dL × 0.01. Results are rounded to 2 decimal places.
Several markers on your report?
See how MedProtect explains results in the app: the whole report, a check of the recognized values, and a clear breakdown.
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