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Anti-thyroglobulin antibodies
Antibodies against the thyroid protein thyroglobulin — a sign of autoimmune thyroid disease that also interferes with thyroglobulin measurement.
Other names: Anti-Tg, thyroglobulin antibodies, TgAbSection: Thyroid
Updated: August 31, 2026·MedProtect editorial team Reference information — not a diagnosis or a prescription
In shortAnti-thyroglobulin antibodies (anti-Tg) appear in autoimmune thyroid conditions such as Hashimoto's thyroiditis. A negative result typically corresponds to values below about 2 IU/mL, but each laboratory sets its own cutoff. They are read together with TPO antibodies, TSH, and thyroid ultrasound.
Reference ranges
Group
Reference range
Result — typical range (international reference, not a national standard)
negative (typical cutoff up to 2 IU/mL (2 kIU/L), method-dependent)
Lab Tests Online notes that each laboratory defines its own negative/positive threshold — the report's reference applies. This is an international typical range, not a national standard.
Check your value
Enter your result — we will show how it compares with a typical range. Match the units of the selected row.
Approximate comparison with a typical range, not a diagnosis. Reference intervals vary by laboratory and method — check your report; result interpretation is done by a doctor.
What this marker is
Thyroglobulin is the storage protein of thyroid hormone inside the gland. When the immune system targets it, anti-Tg antibodies appear — most often in Hashimoto's thyroiditis, sometimes in Graves' disease.
These antibodies matter twice: they signal autoimmunity, and they distort thyroglobulin measurement — which is why thyroglobulin is always reported together with anti-Tg after thyroid cancer surgery.
When it is high
Hashimoto's thyroiditisThe most common cause; usually accompanied by TPO antibodies and a characteristic ultrasound picture.
Graves' diseaseAnti-Tg can accompany the TSH-receptor antibodies that drive the disease.
After thyroid surgery or biopsyManipulation of the gland can transiently raise antibody levels.
When it is low
Expected findingMost healthy people have no detectable anti-Tg antibodies.
What can skew the result
These factors can shift the value without any disease — worth considering before a retest:
Autoimmune thyroid diseaseThyroid surgery and biopsyPregnancy
How to prepare
Blood from a vein; no special preparation.
When a retest makes sense
A positive result is followed with TSH as the endocrinologist advises; antibody levels themselves are not a treatment target.
Who usually reviews this result
A result outside the reference range is usually reviewed by: an endocrinologist. Bring your lab report and any previous results to the appointment.
Names used on lab reports
Your report may use any of these names: Anti-TgTgAbThyroglobulin antibodiesAnti-thyroglobulin
Units and conversion
Measured in: IU/mL
IU/mL=kIU/L
1 IU/mL = 1 kIU/L — the number stays the same. Results are rounded to 2 decimal places.
Several markers on your report?
See how MedProtect explains results in the app: the whole report, a check of the recognized values, and a clear breakdown.
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